Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO
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چکیده
منابع مشابه
Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO
Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling improves symptoms in Alzheimer's disease and schizophrenia. The pharmaceutical study of α7 receptors is hampered because these receptors do not form their functional pentameric structure in cell lines, and mechanisms that underlie α7 recepto...
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Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightly regulated. NACHO was recently identified as a chaperone for α7-type nAChRs. Here, we find NACHO mediates assembly of all major classes of presynapt...
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Progress in the fields of neuroscience and molecular biology has identified the forebrain cholinergic system as being important in many higher order brain functions. Further analysis of the genes encoding the nicotinic acetylcholine receptors (nAChRs) has highlighted, in particular, the role of α7 nAChRs in these higher order brain functions as evidenced by their peculiar physiologic and pharma...
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The interaction between the immune system and the central nervous system is largely unknown and under intense scrutiny by the biomedical community. Research results during the last decades have identified important two-way communication processes between these two systems, mediated by the cytokine network as well as by “classical” neurotransmitters. The dogma of a separate functioning of the tw...
متن کاملAcetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
PURPOSE The α7 nicotinic acetylcholine receptor (nAChR) is widely expressed in the nervous system, including in the inner retinal neurons in all species studied to date. Although reductions in the expression of α7 nAChRs are thought to contribute to the memory and visual deficits reported in Alzheimer's disease (AD) and schizophrenia , the α7 nAChR knockout (KO) mouse is viable and has only sli...
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ژورنال
عنوان ژورنال: Neuron
سال: 2016
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2016.01.018